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Human MSCs are the single most used cell source for tissue engineering and regenerative medicine applications, and clinical trials involving hMSCs have outpaced all other cell types in recent years (see hereand here). However, despite indications of clinical effectiveness (see here and here), there is repeated news of the failure of high-profile MSC trials to demonstrate efficacy in a number of...
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There has been much discussion in the literature and the blogosphere (here, here, and here) lately about keeping track of cellular age, and there is very good reason for this. First, there are multiple regulatory guidelines that propose tracking the age of cells used in biologics manufacturing. Secondly, it is well documented that cell phenotype and function can be compromised the older a cell is.... Read More
Extreme cellular stress can trigger senescence, a mechanism protecting
against malignant cell transformation.
Adapted from:
Kovacic J C et al. Circulation. 2011;123:1650-1660
We’ve mentioned several times on this blog how standardizationof materials, equipment and processes is critical to driving reproducibility and robustness of living cell technologies. As we continue to engage researchers in...
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@JennWebb recently wrote an article for the O’Reilly Radar titled Democratizing Technology and the Road to Empowerment. She starts out the article with a nice summary of what it means to Democratize Technology. Jenn writes “Advancements in technology are making what once was relegated only to highly educated scientists, engineers and developers accessible to — and affordable for — the...
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