Prolific Stem Cell and Cell Therapy Blogger Alexey Bersenev (@cells_nnm on Twitter) has recently written a post on his Cell Trials blog titled "Trends in cell therapy clinical trials 2011 – 2013". If you are interested in Stem Cells and Cell Therapy, it is highly likely that you already know Alexey. He is one of the most passionate and dedicated technologists in the area. If you don't know him,... Read More
INTRODUCTION:

 

Human Mesenchymal Stem/Stromal Cells, or hMSC, are key components of future therapeutics, engineered tissues, and medical devices and are currently in use in over 400 clinical trials (1). Bone marrow-derived MSC (hBM-MSC) have historically been the most widely used hMSC, but hMSC can be isolated from many tissues of the body including fat, umbilical cord blood, dental pulp, Wharton’s...
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<td style="text-align: center;"><a href="http://3.bp.blogspot.com/-jfbWgrplfaU/VFuS4CaFc-I/AAAAAAAADIA/LdW1wE6PyeE/s1600/Misconceptions.jpg" imageanchor="1" style="clear: right; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img src="http://3.bp.blogspot.com/-jfbWgrplfaU/VFuS4CaFc-I/AAAAAAAADIA/LdW1wE6PyeE/s1600/Misconceptions.jpg" height="188" border="0" width="200" /></a></td>
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<td class="tr-caption" style="text-align: center;"> http://andreyev.com.au/wp-content/uploads/Misconceptions.jpg</td>
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<div class="MsoListParagraphCxSpFirst" style="margin-left: 0in; mso-add-space: auto;"><span style="font-family: 'Arial',sans-serif;">We blogged recently about </span><a href="http://roosterbio.blogspot.com/2014/10/current-bottlenecks-in-msc-research.html"><span style="font-family: 'Arial',sans-serif;">Mesenchymal Stem/Stromal Cell (MSC) Misconceptions</span></a><span style="font-family: 'Arial',sans-serif;"> that are holding the translational cell therapy field back, as identified by </span><a href="http://www.scripps.edu/florida/philanthropy/action/phinney-profile.html"><span style="font-family: 'Arial',sans-serif;">Donald Phinney</span></a><span style="font-family: 'Arial',sans-serif;"> and </span><a href="http://www.stromalab.fr/index.php?option=com_content&amp;view=article&amp;id=86&amp;lang=en"><span style="font-family: 'Arial',sans-serif;">Luc Sensebé</span></a><span style="font-family: 'Arial',sans-serif;">. Since we have come to market with our own hMSC product lines, we have spoken with hundreds of MSC researchers and engineers, and we have compiled our own...</span></div> Read More
Human MSCs are the single most used cell source for tissue engineering and regenerative medicine applications, and clinical trials involving hMSCs have outpaced all other cell types in recent years (see hereand here). However, despite indications of clinical effectiveness (see here and here), there is repeated news of the failure of high-profile MSC trials to demonstrate efficacy in a number of...
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<td style="text-align: center;"><a href="http://upload.wikimedia.org/wikipedia/commons/0/05/MSC_homing_capacity.jpg" imageanchor="1" style="clear: right; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img src="http://upload.wikimedia.org/wikipedia/commons/0/05/MSC_homing_capacity.jpg" height="200" border="0" width="320" /></a></td>
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<td class="tr-caption" style="text-align: center;">Genetically-modified MSCs home to tumor cells and<br />accumulate at the tumor site. Image adapted from<br /><a class="external free" href="http://dx.doi.org/10.1016/j.canlet.2011.02.012" rel="nofollow" style="background-color: #f7f7f7; background-image: none; color: #0b0080; font-family: sans-serif; font-size: 10px; line-height: 15px; text-align: left; text-decoration: none;">http://dx.doi.org/10.1016/j.canlet.2011.02.012</a>.</td>
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<div class="MsoNormal" style="line-height: 115%; mso-layout-grid-align: none; mso-pagination: none; text-align: justify; text-autospace: none; text-justify: inter-ideograph;">In the body, MSCs are known to home to sites of acute injury and inflammation and migrate to tumors in response to tumor secretion of growth factors, cytokines, and extracellular matrix (ECM) molecules. However, g<span style="mso-bidi-font-family: 'Times New Roman';">iven their <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833273/">secretion of biomolecules</a>that...</span></div> Read More
@JennWebb recently wrote an article for the O’Reilly Radar titled Democratizing Technology and the Road to Empowerment. She starts out the article with a nice summary of what it means to Democratize Technology. Jenn writes “Advancements in technology are making what once was relegated only to highly educated scientists, engineers and developers accessible to — and affordable for — the...
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Mesenchymal Stem Cells (MSCs) are widely studied in academic circles and an attractive cell source for clinical applications. MSCs not only possess the ability to self-renew and differentiate to a number of mesenchymal lineages in vitro and in vivo [1,2], but these cells also secrete a cadre of potent trophic factors that contribute to tissue remodeling and modulate the host immune response,...
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Everyone at RoosterBio is extremely excited to be launching our company, shipping our first products, and interacting with tissue engineers, cell therapists, synthetic biologists, and our customers to learn about innovative research in these fields, share our knowledge, and contribute to the Cell and Tissue Engineering Revolution. The central theme behind RoosterBio, or what we call our “business... Read More