As we stated in an earlier blog post, standardization of materials, equipment and processes will be critical to drive reproducibility and robustness of living cell technologies to the point where they can be widely used and considered “Democratized”. Some day in the future, an advanced degree and several years of training will not be a pre-requisite for a person to use living cells for some type...
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<td style="text-align: center;"><a href="http://upload.wikimedia.org/wikipedia/commons/0/05/MSC_homing_capacity.jpg" imageanchor="1" style="clear: right; margin-bottom: 1em; margin-left: auto; margin-right: auto;"><img src="http://upload.wikimedia.org/wikipedia/commons/0/05/MSC_homing_capacity.jpg" height="200" border="0" width="320" /></a></td>
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<td class="tr-caption" style="text-align: center;">Genetically-modified MSCs home to tumor cells and<br />accumulate at the tumor site. Image adapted from<br /><a class="external free" href="http://dx.doi.org/10.1016/j.canlet.2011.02.012" rel="nofollow" style="background-color: #f7f7f7; background-image: none; color: #0b0080; font-family: sans-serif; font-size: 10px; line-height: 15px; text-align: left; text-decoration: none;">http://dx.doi.org/10.1016/j.canlet.2011.02.012</a>.</td>
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<div class="MsoNormal" style="line-height: 115%; mso-layout-grid-align: none; mso-pagination: none; text-align: justify; text-autospace: none; text-justify: inter-ideograph;">In the body, MSCs are known to home to sites of acute injury and inflammation and migrate to tumors in response to tumor secretion of growth factors, cytokines, and extracellular matrix (ECM) molecules. However, g<span style="mso-bidi-font-family: 'Times New Roman';">iven their <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833273/">secretion of biomolecules</a>that...</span></div> Read More
@JennWebb recently wrote an article for the O’Reilly Radar titled Democratizing Technology and the Road to Empowerment. She starts out the article with a nice summary of what it means to Democratize Technology. Jenn writes “Advancements in technology are making what once was relegated only to highly educated scientists, engineers and developers accessible to — and affordable for — the...
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Mesenchymal Stem Cells (MSCs) are widely studied in academic circles and an attractive cell source for clinical applications. MSCs not only possess the ability to self-renew and differentiate to a number of mesenchymal lineages in vitro and in vivo [1,2], but these cells also secrete a cadre of potent trophic factors that contribute to tissue remodeling and modulate the host immune response,...
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A lot of discussion on this blog will surround MSCs. So, what is an MSC, why are they relevant, and what’s there to talk about? A little intro:

 

The continuing debate on “What is an MSC”?

 

Adherent bone marrow-derived cells that differentiate down various tissue lineages have traditionally been called Mesenchymal Stem Cells, or MSCs. There is great debate in academic circles whether this is an...
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Everyone at RoosterBio is extremely excited to be launching our company, shipping our first products, and interacting with tissue engineers, cell therapists, synthetic biologists, and our customers to learn about innovative research in these fields, share our knowledge, and contribute to the Cell and Tissue Engineering Revolution. The central theme behind RoosterBio, or what we call our “business... Read More