Paracrine signaling is a form of cell-to-cell communication that has been observed to be responsible for the regenerative power of many cell-based therapies such as mesenchymal stromal cells (MSCs). To ... More

Whether Upstream or Downstream,  EV Manufacturing is Becoming Seaworthy in 2020 Manufacturing and Isolation Methods After exploring the Conference’s highlights (Part I) with basic biology, applied technologies and clinical translation, ... More

To Harness Heterogeneity, Extracellular Vesicle (EV) Differences Explored with Deference Above, a rudimentary mind-map showing many of the topics on display at 2020’s virtual Annual ISEV Meeting.  A major theme ... More

Above, diagram of the hypothesized role of MSCs to disrupt the cycle of neutrophil “NETosis” in COVID-19 lung damage, via its immunomodulatory paracrine activity on Tregs and macrophages. Could human ... More

On May 1st, thought leaders from the ISEV and ISCT published online in Cytotherapy a joint statement, “ISEV and ISCT statement on EVs from MSCs and other cells: considerations for potential ... More

Amid the global search for treatments for COVID-19 related lung disorders, MSCs emerged as one of the promising solutions to treat Acute Respiratory Distress Syndrome (ARDS) [1, 2]. (See our ... More

Authored by Mayasari Lim, PhD, Jonathan Carson, PhD, and Jon A. Rowley, PhD, RoosterBio, Inc. Some research suggests that ARDS might be treatable with the secretome of MSCs. Scientists and ... More

Scalability of EV Manufacturing is a Major Challenge Previously, we discussed the emergence of MSC extracellular vesicles (EVs) as clinical therapies. However, a critical barrier in the development of MSC-EVs as a ... More

MSC-EVs Emerge as a Cell-Free Therapy Extracellular vesicle (EV) interest continues to increase as more evidence emerges about the ability of these lipid-bilayer membrane vesicles to elicit specific responses from ... More