RoosterVial™-hBM-50M-XF are Human Bone-Marrow Derived Mesenchymal Stem/Stromal Cells (hBM-MSCs) isolated from normal healthy adult donors under xeno-free (XF) conditions. This novel high-volume format contains >50M cryopreserved XFF (Xeno-Free Formulated) hBM-MSCs guaranteed to generate >500M cells within 7 days when paired with RoosterNourishTM-MSC-XF bioprocess medium. Our XF hBM-MSCs are isolated from adult human iliac crest and expanded from a variety of normal, healthy donors to a population doubling level (PDL) of 6-10, post-mononuclear cell isolation. Each produced lot is released based on ISCT minimal criteria for hMSC identity including cell surface marker expression and tri-lineage differentiation potential, expansion potential, and sterility. Accompanying QC brief contains industry-leading functional characterization including immunomodulatory potential (IDO assay) and angiogenic cytokine secretion, giving added confidence in quality, reproducibility, and east of integration.
Designed for robust, reproducible, standardized XF scale-up and supported by our 2D and our 3D bioreactor processes. RoosterVial™-hBM-50M-XF can efficiently get you to billions of hMSCs to “Radically Simplify” your Research and Product Development.
Product Features
50M cryopreserved, XF hBM-MSCs per vial
Manufactured with scalable processes and cryopreserved using standard, controlled processes
Supported by 1st in class hMSC identity and functional characterization
Generate 500M cells within 7 days and 5B cells in two weeks or less when cultured with RoosterNourish™-MSC-XF
RoosterVial™-hBM-50M-XF (xeno-free, MSC-032) cultured in RoosterNourish™-MSC-XF (KT-016) have a fibroblastic cell morphology (left) and express hMSC cell surface markers (right).
Immunomodulatory activity (left, IDO activity increase in response to IFNy) and angiogenic cytokine secretion of a representative RoosterVial™-hBM-50M-XF (MSC-032) lot (right).
Trilineage differentiation of RoosterVial™-hBM-50M-XF (MSC-032) of a representative MSC-032 lot. Adipogenesis, left; Osteogenesis, middle; Chondrogenesis, right.
