- Aiming to improve exosome purification process that is currently slowing adoption of promising gene therapies and other new modalities
- A scalable purification process would enable large-scale production of exosomes and yield high purity, potency, and cost-efficiency for clinical use
FREDERICK, MD — Biotechnology leaders Cytiva and RoosterBio, Inc., are teaming up to develop a purification process to manufacture exosomes in mass quantities. This collaboration brings together the strengths of both companies to solve one of the biggest challenges currently limiting the use of exosomes as therapeutics and as delivery vehicles for gene therapies and other biologics.
Exosomes are extracellular vesicles (EVs) that play a critical role in cell-to-cell communication and show therapeutic potential in areas that include cancer, neurodegenerative, and regenerative medicine. Compared to other gene-based therapies, exosomes carry multiple types of genetic material, which can be useful in treating complex disorders that can’t be targeted by viral vectors and lipid nanoparticles.
Emmanuel Abate, President, Genomic Medicine, Cytiva, says: “Current methods for purifying exosomes are often time-consuming and inefficient, which can limit their use in clinical operations. The goal of this collaboration is to develop scalable purification platforms that allow this exciting treatment option to reach its full potential.”
Tim Kelly, Chief Executive Officer of RoosterBio, says: “Exosomes offer a new and uniquely powerful approach for the treatment of a wide range of human health conditions, and robust, scalable, cost-effective manufacturing solutions are essential to realizing this potential. We are delighted to partner with Cytiva to advance our collective exosome technology platforms for clinical and commercial adoption of this exciting new class of therapies.”
Cytiva and RoosterBio will work together to develop high-efficiency purification technologies that enable large-scale exosome production and yield high purity, potency, and cost-efficiency. The data generated through this collaborative effort will be published and shared with the broader life sciences community.
At Cytiva, our mission is to advance and accelerate the development of therapeutics. With nearly 16 000 associates in more than 40 countries, we’re driven to use our expertise and talent to achieve better flexibility, capacity, and efficiency for our customers. Our broad and deep portfolio of tools and technologies, global scale, and best-in-class service provides critical support from discovery to delivery, for customers spanning researchers, emerging biotech, large-scale biopharma, and contract manufacturers. Learn more at cytiva.com.
RoosterBio accelerates human mesenchymal stem/stromal cell (hMSC) and extracellular vesicle (EV) product and process development to fuel the rapid implementation of scalable advanced therapies. Our high-quality hMSCs, bioprocess media, genetic engineering tools, and EV production solutions are paired with expert bioprocessing knowledge to progress therapeutic developers from concept to first-in-human testing and commercial manufacturing at reduced cost and increased productivity. With optimized, scalable processes, Type 2 Master Files, and cGMP products, we have enabled therapeutic programs to traverse their path to clinical translation in under 1 year. RoosterBio is driven by clients’ success and creating a world where safe and effective regenerative medicines are rapidly developed and widely available on a global scale.