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Overview

The Xeno-Free Bioreactor Scale-Up Bundle is designed for process development into the PBS Biotech 3L bioreactor – reaching >1B hMSCs at a consistent population doubling level (PDL). The bundle consists of a vial of 10M XF hMSCs, adequate XF bioprocess media to generate the seed stock and perform a 3L fed-batch expansion, and a 3L bioreactor vessel.

Versus leading solutions, achieve 500K cells/mL for a fraction of the time and a fraction of the cost.

Per our protocols and process recommendations for XF bioreactor cell culture, RoosterBio suggests using Corning® Low Concentration Synthemax® II Microcarriers (3781). Our system is also compatible with Corning CellBIND® Microcarriers (3779).

Intended Use: Research Use Only

Product Features

• Each component included is set for a single 3L bioreactor run – 1 x RoosterVial™-hBM-10M-XF (10 million hBM-MSCs, MSC-030) + 8 x RoosterNourish™-MSC-XF (8 x 500 mL, KT-016) + 6 x RoosterReplenish™-MSC-XF (6 x 10 mL, SU-023) + 1 PBS 3L disposable bioreactor vessel (3 L)
• A bundle and key process parameters for small scale process development – in a platform that can be taken to >50L
• Rapidly generate >1B hMSCs
• Highly productive: supports industry-leading productivity metrics
• Outperforms other feed regimens
• Translation-friendly
• Backed by 2D to 3D comparability data
• Compact, low shear bioreactor system

A PBS Biotech bioreactor controller is required to run this scale-up bundle. This must be ordered separately through PBS at sales@pbsbiotech.com.

Microcarriers not included – 4 vials required